Effect of Photoperiod and Lethal Yellow Mutation on Depression-Like Behavior and Expression of Proinflammatory Cytokines in the Hypothalamus in Mice
- Authors: Fursenko D.V.1, Bazhenova E.Y.1, Khotskin N.V.1, Sorokin I.E.1, Kulikova E.A.1, Kulikov A.V.1
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Affiliations:
- Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Issue: Vol 167, No 1 (2019)
- Pages: 100-103
- Section: Experimental Biology
- URL: https://journals.rcsi.science/0007-4888/article/view/241489
- DOI: https://doi.org/10.1007/s10517-019-04470-8
- ID: 241489
Cite item
Abstract
We studied the influence of obesity caused by lethal yellow (AY) mutation in the agouti gene, short photoperiod (4/20 h light/darkness), and combination of these factors on depressive-like behavior in the forced swimming test and expression of genes encoding proinflammatory cytokines in the hypothalamus of heterozygous male C57Bl/6-AY/a mice and their wild-type littermate controls (C57Bl/6-a/a). It was shown that AY mutation as well as short photoperiod increased depressive-like behavior in mice. No effect of the interaction of AY mutation and photoperiod on immobility in the forced swimming test was revealed. In wild-type mice, increased depressive-like behavior caused by short photoperiod was accompanied by enhanced expression of Tnf gene. Exposure to short daylight increased the expression of Nos2.
About the authors
D. V. Fursenko
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Author for correspondence.
Email: dvfursenko@outlook.com
Russian Federation, Novosibirsk
E. Yu. Bazhenova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: dvfursenko@outlook.com
Russian Federation, Novosibirsk
N. V. Khotskin
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: dvfursenko@outlook.com
Russian Federation, Novosibirsk
I. E. Sorokin
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: dvfursenko@outlook.com
Russian Federation, Novosibirsk
E. A. Kulikova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: dvfursenko@outlook.com
Russian Federation, Novosibirsk
A. V. Kulikov
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: dvfursenko@outlook.com
Russian Federation, Novosibirsk