Correlations between the Levels of the Main Extracellular Matrix Components in Mouse Liver in Chronic BCG-Induced Granulomatosis
- 作者: Kim L.1, Shkurupy V.1,2, Putyatina A.1
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隶属关系:
- Federal Research Center of Fundamental and Translational Medicine
- Novosibirsk State Medical University, Ministry of Health of the Russian Federation
- 期: 卷 166, 编号 4 (2019)
- 页面: 469-472
- 栏目: Immunology and Microbiology
- URL: https://journals.rcsi.science/0007-4888/article/view/241113
- DOI: https://doi.org/10.1007/s10517-019-04374-7
- ID: 241113
如何引用文章
详细
Correlations between extracellular matrix components in mouse liver revealed the pathogenetically determined dynamic structure of these interrelations (some correlations appeared while others disappeared) at various terms of BCG-induced granulomatosis. The correlations between the studied parameters were strong during the first (postinfection days 3-10) and the second (postinfection days 60-90) periods but became moderate during the third period manifested by chronic inflammation (postinjection day 180). The greatest number of correlations was observed at the beginning of the stabilization period (postinjection day 60). At this period, the content of all structural components of hepatic proteoglycans closely correlated with that of hydroxyproline. These findings attested to systemic changes in metabolism of extracellular matrix components and interrelation between some structural units of proteoglycans in the liver and the components of extracellular matrix in the lungs. The common and typical organ-specific correlations in the liver and lungs suggest the existence of correlations between different organs during progression of BCG-induced granulomatosis.
作者简介
L. Kim
Federal Research Center of Fundamental and Translational Medicine
编辑信件的主要联系方式.
Email: lenkim@centercem.ru
俄罗斯联邦, Novosibirsk
V. Shkurupy
Federal Research Center of Fundamental and Translational Medicine; Novosibirsk State Medical University, Ministry of Health of the Russian Federation
Email: lenkim@centercem.ru
俄罗斯联邦, Novosibirsk; Novosibirsk
A. Putyatina
Federal Research Center of Fundamental and Translational Medicine
Email: lenkim@centercem.ru
俄罗斯联邦, Novosibirsk