Infradian Rhythms of Resistance to a Dissociative Anesthetic in Wistar Male Rats under Normal Conditions and After Surgical Removal of the Adrenal Glands and Testes
- 作者: Dzalilova D.1, Diatroptova M.1, Mkhitarov V.1, Diatroptov M.1
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隶属关系:
- Research Institute of Human Morphology
- 期: 卷 166, 编号 3 (2019)
- 页面: 413-416
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241063
- DOI: https://doi.org/10.1007/s10517-019-04362-x
- ID: 241063
如何引用文章
详细
Daily dynamics of changes in the latency of a response to dissociative anesthetic tiletamine (time from injection to ataxia) was studied in mature Wistar rats. Both intramuscular and intravenous administration of the anesthetic was associated with 4-day oscillations of the latent period synchronous with the dynamics of changes in the concentration of glucocorticoid hormones. The period and phases of the infradian rhythm of resistance to the anesthetic remained unchanged after removal of both adrenal glands and testes and administration of corticosterone synthesis blocker trilostane diminishing the 4-day cycle of changes in corticosterone level. Therefore, hormones of the adrenal glands and testes do not play the key role in the mechanisms of formation of the 4-day infradian rhythm.
作者简介
D. Dzalilova
Research Institute of Human Morphology
Email: diatrom@inbox.ru
俄罗斯联邦, Moscow
M. Diatroptova
Research Institute of Human Morphology
Email: diatrom@inbox.ru
俄罗斯联邦, Moscow
V. Mkhitarov
Research Institute of Human Morphology
Email: diatrom@inbox.ru
俄罗斯联邦, Moscow
M. Diatroptov
Research Institute of Human Morphology
编辑信件的主要联系方式.
Email: diatrom@inbox.ru
俄罗斯联邦, Moscow