Infradian Rhythms of Resistance to a Dissociative Anesthetic in Wistar Male Rats under Normal Conditions and After Surgical Removal of the Adrenal Glands and Testes
- Авторы: Dzalilova D.1, Diatroptova M.1, Mkhitarov V.1, Diatroptov M.1
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Учреждения:
- Research Institute of Human Morphology
- Выпуск: Том 166, № 3 (2019)
- Страницы: 413-416
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241063
- DOI: https://doi.org/10.1007/s10517-019-04362-x
- ID: 241063
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Аннотация
Daily dynamics of changes in the latency of a response to dissociative anesthetic tiletamine (time from injection to ataxia) was studied in mature Wistar rats. Both intramuscular and intravenous administration of the anesthetic was associated with 4-day oscillations of the latent period synchronous with the dynamics of changes in the concentration of glucocorticoid hormones. The period and phases of the infradian rhythm of resistance to the anesthetic remained unchanged after removal of both adrenal glands and testes and administration of corticosterone synthesis blocker trilostane diminishing the 4-day cycle of changes in corticosterone level. Therefore, hormones of the adrenal glands and testes do not play the key role in the mechanisms of formation of the 4-day infradian rhythm.
Об авторах
D. Dzalilova
Research Institute of Human Morphology
Email: diatrom@inbox.ru
Россия, Moscow
M. Diatroptova
Research Institute of Human Morphology
Email: diatrom@inbox.ru
Россия, Moscow
V. Mkhitarov
Research Institute of Human Morphology
Email: diatrom@inbox.ru
Россия, Moscow
M. Diatroptov
Research Institute of Human Morphology
Автор, ответственный за переписку.
Email: diatrom@inbox.ru
Россия, Moscow