Visualization and Cytotoxicity of Fluorescence-Labeled Dimeric Magnetite-Gold Nanoparticles Conjugated with Prostate-Specific Membrane Antigen in Mouse Macrophages
- 作者: Pirutin S.1,2, Efremova M.1,3, Yusipovich A.1, Turovetskii V.1, Maksimov G.1, Druzhko A.2, Mazhuga A.1,3,4
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隶属关系:
- M. V. Lomonosov Moscow State University
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- National University of Science and Technology MISIS
- D. I. Mendeleev University of Chemical Technology of Russia
- 期: 卷 166, 编号 3 (2019)
- 页面: 386-389
- 栏目: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/241026
- DOI: https://doi.org/10.1007/s10517-019-04356-9
- ID: 241026
如何引用文章
详细
We demonstrated the possibility of penetration of magnetite-gold nanoparticles conjugated with prostate-specific membrane antigen into mouse macrophages. It was found that after 3-h incubation with nanoparticles in a concentration of 15 mg/liter at 37oC, they were seen in only 13% macrophages. In about 90% cells, the nanoparticles were detected within the cytoplasm. Under these conditions, membrane damage was revealed in 25% cells. These results should be taken into account in further development and application of nanomaterials for diagnostic and therapeutic purposes in oncology.
作者简介
S. Pirutin
M. V. Lomonosov Moscow State University; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: pirutin@yandex.ru
俄罗斯联邦, Moscow; Pushchino, Moscow Region
M. Efremova
M. V. Lomonosov Moscow State University; National University of Science and Technology MISIS
Email: pirutin@yandex.ru
俄罗斯联邦, Moscow; Moscow
A. Yusipovich
M. V. Lomonosov Moscow State University
Email: pirutin@yandex.ru
俄罗斯联邦, Moscow
V. Turovetskii
M. V. Lomonosov Moscow State University
Email: pirutin@yandex.ru
俄罗斯联邦, Moscow
G. Maksimov
M. V. Lomonosov Moscow State University
Email: pirutin@yandex.ru
俄罗斯联邦, Moscow
A. Druzhko
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: pirutin@yandex.ru
俄罗斯联邦, Pushchino, Moscow Region
A. Mazhuga
M. V. Lomonosov Moscow State University; National University of Science and Technology MISIS; D. I. Mendeleev University of Chemical Technology of Russia
Email: pirutin@yandex.ru
俄罗斯联邦, Moscow; Moscow; Moscow