Semaphorin 3A Negatively Affects Proliferation of Mouse Thymus Epithelial Cells In Vitro
- 作者: Rutto K.1, Ovsyukov K.1, Kudryavtsev I.1, Kiseleva E.1,2
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隶属关系:
- Institute of Experimental Medicine
- I. I. Mechnikov North-Western State Medical University
- 期: 卷 166, 编号 3 (2019)
- 页面: 339-343
- 栏目: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/241003
- DOI: https://doi.org/10.1007/s10517-019-04346-x
- ID: 241003
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详细
We studied effects of semaphorin 3A, keratinocyte growth factor (KGF), hepatocyte growth factor (HGF), and their combinations on the proliferative activity of cortical (cTEC1-2) and medullary (mTEC3-10) thymus epithelium cell lines. Semaphorin 3A inhibited the proliferative activity of epithelial cells, while HGF and KGF, in contrast, exerted a stimulating effect. The effect of KGF and semaphorin 3A on different cell lines depended on the expression of receptors for these two factors. When the combination of two factors was used, semaphorin 3A was able to neutralize the stimulating effect of HGF and KGF. It can be assumed that semaphorin 3A synthesized in the thymus stroma, can act as a functional antagonist of HGF and KGF and have an inhibitory effect when these drugs are administered into the body for the therapeutic purpose of restoring thymus functions.
作者简介
K. Rutto
Institute of Experimental Medicine
编辑信件的主要联系方式.
Email: krispins-90@mail.ru
俄罗斯联邦, St. Petersburg
K. Ovsyukov
Institute of Experimental Medicine
Email: krispins-90@mail.ru
俄罗斯联邦, St. Petersburg
I. Kudryavtsev
Institute of Experimental Medicine
Email: krispins-90@mail.ru
俄罗斯联邦, St. Petersburg
E. Kiseleva
Institute of Experimental Medicine; I. I. Mechnikov North-Western State Medical University
Email: krispins-90@mail.ru
俄罗斯联邦, St. Petersburg; St. Petersburg