Semaphorin 3A Negatively Affects Proliferation of Mouse Thymus Epithelial Cells In Vitro
- Авторы: Rutto K.1, Ovsyukov K.1, Kudryavtsev I.1, Kiseleva E.1,2
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Учреждения:
- Institute of Experimental Medicine
- I. I. Mechnikov North-Western State Medical University
- Выпуск: Том 166, № 3 (2019)
- Страницы: 339-343
- Раздел: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/241003
- DOI: https://doi.org/10.1007/s10517-019-04346-x
- ID: 241003
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Аннотация
We studied effects of semaphorin 3A, keratinocyte growth factor (KGF), hepatocyte growth factor (HGF), and their combinations on the proliferative activity of cortical (cTEC1-2) and medullary (mTEC3-10) thymus epithelium cell lines. Semaphorin 3A inhibited the proliferative activity of epithelial cells, while HGF and KGF, in contrast, exerted a stimulating effect. The effect of KGF and semaphorin 3A on different cell lines depended on the expression of receptors for these two factors. When the combination of two factors was used, semaphorin 3A was able to neutralize the stimulating effect of HGF and KGF. It can be assumed that semaphorin 3A synthesized in the thymus stroma, can act as a functional antagonist of HGF and KGF and have an inhibitory effect when these drugs are administered into the body for the therapeutic purpose of restoring thymus functions.
Об авторах
K. Rutto
Institute of Experimental Medicine
Автор, ответственный за переписку.
Email: krispins-90@mail.ru
Россия, St. Petersburg
K. Ovsyukov
Institute of Experimental Medicine
Email: krispins-90@mail.ru
Россия, St. Petersburg
I. Kudryavtsev
Institute of Experimental Medicine
Email: krispins-90@mail.ru
Россия, St. Petersburg
E. Kiseleva
Institute of Experimental Medicine; I. I. Mechnikov North-Western State Medical University
Email: krispins-90@mail.ru
Россия, St. Petersburg; St. Petersburg