Semaphorin 3A Negatively Affects Proliferation of Mouse Thymus Epithelial Cells In Vitro
- Авторлар: Rutto K.1, Ovsyukov K.1, Kudryavtsev I.1, Kiseleva E.1,2
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Мекемелер:
- Institute of Experimental Medicine
- I. I. Mechnikov North-Western State Medical University
- Шығарылым: Том 166, № 3 (2019)
- Беттер: 339-343
- Бөлім: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/241003
- DOI: https://doi.org/10.1007/s10517-019-04346-x
- ID: 241003
Дәйексөз келтіру
Аннотация
We studied effects of semaphorin 3A, keratinocyte growth factor (KGF), hepatocyte growth factor (HGF), and their combinations on the proliferative activity of cortical (cTEC1-2) and medullary (mTEC3-10) thymus epithelium cell lines. Semaphorin 3A inhibited the proliferative activity of epithelial cells, while HGF and KGF, in contrast, exerted a stimulating effect. The effect of KGF and semaphorin 3A on different cell lines depended on the expression of receptors for these two factors. When the combination of two factors was used, semaphorin 3A was able to neutralize the stimulating effect of HGF and KGF. It can be assumed that semaphorin 3A synthesized in the thymus stroma, can act as a functional antagonist of HGF and KGF and have an inhibitory effect when these drugs are administered into the body for the therapeutic purpose of restoring thymus functions.
Авторлар туралы
K. Rutto
Institute of Experimental Medicine
Хат алмасуға жауапты Автор.
Email: krispins-90@mail.ru
Ресей, St. Petersburg
K. Ovsyukov
Institute of Experimental Medicine
Email: krispins-90@mail.ru
Ресей, St. Petersburg
I. Kudryavtsev
Institute of Experimental Medicine
Email: krispins-90@mail.ru
Ресей, St. Petersburg
E. Kiseleva
Institute of Experimental Medicine; I. I. Mechnikov North-Western State Medical University
Email: krispins-90@mail.ru
Ресей, St. Petersburg; St. Petersburg