Effect of Neoadjuvant and Adjuvant Therapy of Experimental Breast Cancer on the Structure of Mesenteric Lymph Nodes
- 作者: Kazakov O.1, Kabakov A.1, Poveshchenko A.1, Raiter T.1, Strunkin D.1, Poveshchenko O.1, Lykov A.1, Konenkov V.1
-
隶属关系:
- Research Institute of Experimental and Clinical Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- 期: 卷 166, 编号 2 (2018)
- 页面: 245-249
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240932
- DOI: https://doi.org/10.1007/s10517-018-4324-2
- ID: 240932
如何引用文章
详细
The morphometric analysis of mesenteric lymph nodes was carried out in female Wistar rats with chemically induced breast cancer. In control rats with untreated breast cancer, the volume of the system of sinuses increased in parallel with the appearance of morphological signs of suppression of cell-mediated immunity, inhibition of humoral immunity, and macrophage reaction. Against the background of chemotherapy, we observed a decrease in the volume of paracortex and lymphoid nodules, suppression of proliferative activity of lymphoid cells in paracortical and B-cell zone, and a decrease in macrophage content. After resection of breast cancer followed by chemotherapy course, lymph transport activation, widening of the paracortex, enhanced proliferative activity of cells in the paracortex and B-cell zone, and reduced volumes of lymphoid nodules with and without germinal centers and medullary substance were revealed in comparison with rats subjected neoadjuvant chemotherapy.
作者简介
O. Kazakov
Research Institute of Experimental and Clinical Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: kazakoff_oleg@mail.ru
俄罗斯联邦, Novosibirsk
A. Kabakov
Research Institute of Experimental and Clinical Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: kazakoff_oleg@mail.ru
俄罗斯联邦, Novosibirsk
A. Poveshchenko
Research Institute of Experimental and Clinical Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: kazakoff_oleg@mail.ru
俄罗斯联邦, Novosibirsk
T. Raiter
Research Institute of Experimental and Clinical Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: kazakoff_oleg@mail.ru
俄罗斯联邦, Novosibirsk
D. Strunkin
Research Institute of Experimental and Clinical Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: kazakoff_oleg@mail.ru
俄罗斯联邦, Novosibirsk
O. Poveshchenko
Research Institute of Experimental and Clinical Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: kazakoff_oleg@mail.ru
俄罗斯联邦, Novosibirsk
A. Lykov
Research Institute of Experimental and Clinical Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: kazakoff_oleg@mail.ru
俄罗斯联邦, Novosibirsk
V. Konenkov
Research Institute of Experimental and Clinical Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: kazakoff_oleg@mail.ru
俄罗斯联邦, Novosibirsk
![](/img/style/loading.gif)