Effect of Neoadjuvant and Adjuvant Therapy of Experimental Breast Cancer on the Structure of Mesenteric Lymph Nodes
- Authors: Kazakov O.V.1, Kabakov A.V.1, Poveshchenko A.F.1, Raiter T.V.1, Strunkin D.N.1, Poveshchenko O.V.1, Lykov A.P.1, Konenkov V.I.1
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Affiliations:
- Research Institute of Experimental and Clinical Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Issue: Vol 166, No 2 (2018)
- Pages: 245-249
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240932
- DOI: https://doi.org/10.1007/s10517-018-4324-2
- ID: 240932
Cite item
Abstract
The morphometric analysis of mesenteric lymph nodes was carried out in female Wistar rats with chemically induced breast cancer. In control rats with untreated breast cancer, the volume of the system of sinuses increased in parallel with the appearance of morphological signs of suppression of cell-mediated immunity, inhibition of humoral immunity, and macrophage reaction. Against the background of chemotherapy, we observed a decrease in the volume of paracortex and lymphoid nodules, suppression of proliferative activity of lymphoid cells in paracortical and B-cell zone, and a decrease in macrophage content. After resection of breast cancer followed by chemotherapy course, lymph transport activation, widening of the paracortex, enhanced proliferative activity of cells in the paracortex and B-cell zone, and reduced volumes of lymphoid nodules with and without germinal centers and medullary substance were revealed in comparison with rats subjected neoadjuvant chemotherapy.
About the authors
O. V. Kazakov
Research Institute of Experimental and Clinical Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Author for correspondence.
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
A. V. Kabakov
Research Institute of Experimental and Clinical Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
A. F. Poveshchenko
Research Institute of Experimental and Clinical Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
T. V. Raiter
Research Institute of Experimental and Clinical Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
D. N. Strunkin
Research Institute of Experimental and Clinical Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
O. V. Poveshchenko
Research Institute of Experimental and Clinical Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
A. P. Lykov
Research Institute of Experimental and Clinical Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
V. I. Konenkov
Research Institute of Experimental and Clinical Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: kazakoff_oleg@mail.ru
Russian Federation, Novosibirsk
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