Effect of 30-Day Hindlimb Unloading and Hypergravity on Bone Marrow Stromal Progenitors in C57Bl/6N Mice
- 作者: Markina E.1, Andrianova I.1, Shtemberg A.1, Buravkova L.1
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隶属关系:
- State Research Center Institute of Biomedical Problems, Russian Academy of Sciences
- 期: 卷 166, 编号 1 (2018)
- 页面: 130-134
- 栏目: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/240868
- DOI: https://doi.org/10.1007/s10517-018-4301-9
- ID: 240868
如何引用文章
详细
We studied the effect of 30-day hindlimb unloading and subsequent simulated hypergravity on the cellularity and proliferative, clonogenic, and differentiation potential of bone marrow stromal progenitors in mice. Clonogenic and differentiation activity of stromal cells decreased after unloading; proliferative and differentiation activity of bone marrow stromal progenitors increased after hypergravity simulation. Our findings demonstrated negative effect of unloading on functional activity of mouse bone marrow stromal progenitors. Short-term hypergravity after unloading produced a stimulating effect on the bone marrow stromal progenitors.
作者简介
E. Markina
State Research Center Institute of Biomedical Problems, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: goncharova-tim@list.ru
俄罗斯联邦, Moscow
I. Andrianova
State Research Center Institute of Biomedical Problems, Russian Academy of Sciences
Email: goncharova-tim@list.ru
俄罗斯联邦, Moscow
A. Shtemberg
State Research Center Institute of Biomedical Problems, Russian Academy of Sciences
Email: goncharova-tim@list.ru
俄罗斯联邦, Moscow
L. Buravkova
State Research Center Institute of Biomedical Problems, Russian Academy of Sciences
Email: goncharova-tim@list.ru
俄罗斯联邦, Moscow