New Experimental Facts on the Influence of Secondary Immunodeficiency on the Morphology and Biological Activity of Colorectal Tumor
- 作者: Struchko G.1, Merkulova L.1, Moskvichev E.1, Kostrova O.1, Mikhailova M.1
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隶属关系:
- Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University
- 期: 卷 166, 编号 1 (2018)
- 页面: 75-79
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240841
- DOI: https://doi.org/10.1007/s10517-018-4292-6
- ID: 240841
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详细
Colorectal tumors were studied 5 months after carcinogen injection to outbred albino rats with secondary immunodeficiency by common histological and immunobiochemical methods with the use of monoclonal and polyclonal antibodies to Ki-67, Bcl-2, p53, and VEGF. Injection of carcinogen to intact animals led to the formation of adenocarcinomas with high and moderate cell differentiation in the colon, while injection of carcinogen to animals with immunodeficiency was associated with a 1.5-fold higher incidence of GRADE 2 and GRADE 3 adenocarcinomas with more aggressive morphological phenotype and appearance of distant metastases.
作者简介
G. Struchko
Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University
编辑信件的主要联系方式.
Email: glebstr@mail.ru
俄罗斯联邦, Cheboksary, Chuvash Republic
L. Merkulova
Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University
Email: glebstr@mail.ru
俄罗斯联邦, Cheboksary, Chuvash Republic
E. Moskvichev
Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University
Email: glebstr@mail.ru
俄罗斯联邦, Cheboksary, Chuvash Republic
O. Kostrova
Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University
Email: glebstr@mail.ru
俄罗斯联邦, Cheboksary, Chuvash Republic
M. Mikhailova
Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University
Email: glebstr@mail.ru
俄罗斯联邦, Cheboksary, Chuvash Republic