New Experimental Facts on the Influence of Secondary Immunodeficiency on the Morphology and Biological Activity of Colorectal Tumor
- Autores: Struchko G.1, Merkulova L.1, Moskvichev E.1, Kostrova O.1, Mikhailova M.1
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Afiliações:
- Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University
- Edição: Volume 166, Nº 1 (2018)
- Páginas: 75-79
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240841
- DOI: https://doi.org/10.1007/s10517-018-4292-6
- ID: 240841
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Resumo
Colorectal tumors were studied 5 months after carcinogen injection to outbred albino rats with secondary immunodeficiency by common histological and immunobiochemical methods with the use of monoclonal and polyclonal antibodies to Ki-67, Bcl-2, p53, and VEGF. Injection of carcinogen to intact animals led to the formation of adenocarcinomas with high and moderate cell differentiation in the colon, while injection of carcinogen to animals with immunodeficiency was associated with a 1.5-fold higher incidence of GRADE 2 and GRADE 3 adenocarcinomas with more aggressive morphological phenotype and appearance of distant metastases.
Sobre autores
G. Struchko
Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University
Autor responsável pela correspondência
Email: glebstr@mail.ru
Rússia, Cheboksary, Chuvash Republic
L. Merkulova
Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University
Email: glebstr@mail.ru
Rússia, Cheboksary, Chuvash Republic
E. Moskvichev
Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University
Email: glebstr@mail.ru
Rússia, Cheboksary, Chuvash Republic
O. Kostrova
Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University
Email: glebstr@mail.ru
Rússia, Cheboksary, Chuvash Republic
M. Mikhailova
Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University
Email: glebstr@mail.ru
Rússia, Cheboksary, Chuvash Republic