New Experimental Facts on the Influence of Secondary Immunodeficiency on the Morphology and Biological Activity of Colorectal Tumor
- Авторы: Struchko G.1, Merkulova L.1, Moskvichev E.1, Kostrova O.1, Mikhailova M.1
-
Учреждения:
- Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University
- Выпуск: Том 166, № 1 (2018)
- Страницы: 75-79
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240841
- DOI: https://doi.org/10.1007/s10517-018-4292-6
- ID: 240841
Цитировать
Аннотация
Colorectal tumors were studied 5 months after carcinogen injection to outbred albino rats with secondary immunodeficiency by common histological and immunobiochemical methods with the use of monoclonal and polyclonal antibodies to Ki-67, Bcl-2, p53, and VEGF. Injection of carcinogen to intact animals led to the formation of adenocarcinomas with high and moderate cell differentiation in the colon, while injection of carcinogen to animals with immunodeficiency was associated with a 1.5-fold higher incidence of GRADE 2 and GRADE 3 adenocarcinomas with more aggressive morphological phenotype and appearance of distant metastases.
Об авторах
G. Struchko
Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University
Автор, ответственный за переписку.
Email: glebstr@mail.ru
Россия, Cheboksary, Chuvash Republic
L. Merkulova
Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University
Email: glebstr@mail.ru
Россия, Cheboksary, Chuvash Republic
E. Moskvichev
Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University
Email: glebstr@mail.ru
Россия, Cheboksary, Chuvash Republic
O. Kostrova
Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University
Email: glebstr@mail.ru
Россия, Cheboksary, Chuvash Republic
M. Mikhailova
Department of Normal and Topographic Anatomy with Operative Surgery, I. N. Ulyanov Chuvash State University
Email: glebstr@mail.ru
Россия, Cheboksary, Chuvash Republic