Blood Pressure Changes After Exposures Increasing Angiotensin-Converting Enzyme Activity and After Its Normalization with Dihydroquercetin in Male Wistar Rats
- 作者: Korystova A.1, Kublik L.1, Levitman M.1, Shaposhnikova V.1, Kim Y.2, Slashcheva G.3, Lobanov A.3, Tukhovskaya E.3, Korystov Y.1
-
隶属关系:
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- Institute of Cell Biophysics, Russian Academy of Sciences
- Affiliated Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- 期: 卷 166, 编号 1 (2018)
- 页面: 31-34
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240807
- DOI: https://doi.org/10.1007/s10517-018-4282-8
- ID: 240807
如何引用文章
详细
Changes in BP and HR were assessed after exposures increasing activity of angiotensin-converting enzyme: ionizing radiation, NO synthase inhibitor (L-NAME), and dexamethasone. Effects of dihydroquercetin and angiotensin-converting enzyme inhibitor enalapril on activity of this enzyme, BP, and HR were also evaluated under these exposures. Wistar male rats were subjected to X-ray irradiation in a dose of 2.5 Gy. Angiotensin-converting enzyme activity in the aorta sections was determined by Hip-His-Leu hydrolysis. BP and HR were recorded using a non-invasive tail-cuff method and PowerLab 8/35 software. BP and HR were not altered with the increase in activity of angiotensin-converting enzyme after irradiation. In case of prolonged (7 days) treatment with NO synthase inhibitor and dexamethasone, the increase in enzyme activity was accompanied by elevation of BP and, in the case of NO synthase inhibitor, HR reduction. Dihydroquercetin normalized the enzyme activity and lowered BP, but not to the normal level. Enalapril normalized BP, increased by NO synthase inhibitor solution intake; at the same time, the angiotensinconverting enzyme activity decreased more than 2-fold in comparison with the normal.
作者简介
A. Korystova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: ykorystov@rambler.ru
俄罗斯联邦, Moscow
L. Kublik
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Moscow
M. Levitman
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Moscow
V. Shaposhnikova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Moscow
Yu. Kim
Institute of Cell Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Moscow
G. Slashcheva
Affiliated Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Pushchino
A. Lobanov
Affiliated Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Pushchino
E. Tukhovskaya
Affiliated Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Pushchino
Yu. Korystov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
俄罗斯联邦, Moscow