Blood Pressure Changes After Exposures Increasing Angiotensin-Converting Enzyme Activity and After Its Normalization with Dihydroquercetin in Male Wistar Rats
- Autores: Korystova A.1, Kublik L.1, Levitman M.1, Shaposhnikova V.1, Kim Y.2, Slashcheva G.3, Lobanov A.3, Tukhovskaya E.3, Korystov Y.1
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Afiliações:
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- Institute of Cell Biophysics, Russian Academy of Sciences
- Affiliated Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Edição: Volume 166, Nº 1 (2018)
- Páginas: 31-34
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240807
- DOI: https://doi.org/10.1007/s10517-018-4282-8
- ID: 240807
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Resumo
Changes in BP and HR were assessed after exposures increasing activity of angiotensin-converting enzyme: ionizing radiation, NO synthase inhibitor (L-NAME), and dexamethasone. Effects of dihydroquercetin and angiotensin-converting enzyme inhibitor enalapril on activity of this enzyme, BP, and HR were also evaluated under these exposures. Wistar male rats were subjected to X-ray irradiation in a dose of 2.5 Gy. Angiotensin-converting enzyme activity in the aorta sections was determined by Hip-His-Leu hydrolysis. BP and HR were recorded using a non-invasive tail-cuff method and PowerLab 8/35 software. BP and HR were not altered with the increase in activity of angiotensin-converting enzyme after irradiation. In case of prolonged (7 days) treatment with NO synthase inhibitor and dexamethasone, the increase in enzyme activity was accompanied by elevation of BP and, in the case of NO synthase inhibitor, HR reduction. Dihydroquercetin normalized the enzyme activity and lowered BP, but not to the normal level. Enalapril normalized BP, increased by NO synthase inhibitor solution intake; at the same time, the angiotensinconverting enzyme activity decreased more than 2-fold in comparison with the normal.
Sobre autores
A. Korystova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Autor responsável pela correspondência
Email: ykorystov@rambler.ru
Rússia, Moscow
L. Kublik
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
Rússia, Moscow
M. Levitman
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
Rússia, Moscow
V. Shaposhnikova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
Rússia, Moscow
Yu. Kim
Institute of Cell Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
Rússia, Moscow
G. Slashcheva
Affiliated Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ykorystov@rambler.ru
Rússia, Pushchino
A. Lobanov
Affiliated Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ykorystov@rambler.ru
Rússia, Pushchino
E. Tukhovskaya
Affiliated Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: ykorystov@rambler.ru
Rússia, Pushchino
Yu. Korystov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: ykorystov@rambler.ru
Rússia, Moscow