Polyunsaturated Fatty Acids and Their Correlations with Parameters of Oxidative/Antioxidant Potential of the Blood and Lipoprotein-Associated Phospholipase A2 in Coronary Atherosclerosis
- 作者: Shramko V.1, Polonskaya Y.1, Morozov S.2, Chernyak E.2, Chernyavsky A.3, Ragino Y.1
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隶属关系:
- Research Institute of Internal and Preventive Medicine, Affiliated Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
- E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
- 期: 卷 166, 编号 1 (2018)
- 页面: 11-14
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240794
- DOI: https://doi.org/10.1007/s10517-018-4277-5
- ID: 240794
如何引用文章
详细
We studied serum content of some polyunsaturated fatty acids and their correlations with parameters of oxidative stress (FORT), antioxidant protection (FORD), lipoprotein-associated phospholipase A2 (LP-PLA2), and serum level of LPO products in male patients with coronary atherosclerosis. The mass fraction of polyunsaturated fatty acids and FORD were lower, while LP-PLA2, FORT, and concentration of LPO products were higher than in the control group (conventionally healthy men). Negative correlations of medium strength of polyunsaturated fatty acids with inflammation markers and oxidative stress were revealed, which can indicate that the decrease in polyunsaturated fatty acids content is associated with enhanced generation of free radicals, and consequently with increased risk of early atherosclerosis development.
作者简介
V. Shramko
Research Institute of Internal and Preventive Medicine, Affiliated Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: nosova@211.ru
俄罗斯联邦, Novosibirsk
YA. Polonskaya
Research Institute of Internal and Preventive Medicine, Affiliated Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: nosova@211.ru
俄罗斯联邦, Novosibirsk
S. Morozov
N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: nosova@211.ru
俄罗斯联邦, Novosibirsk
E. Chernyak
N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: nosova@211.ru
俄罗斯联邦, Novosibirsk
A. Chernyavsky
E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Email: nosova@211.ru
俄罗斯联邦, Novosibirsk
Yu. Ragino
Research Institute of Internal and Preventive Medicine, Affiliated Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: nosova@211.ru
俄罗斯联邦, Novosibirsk
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