Email this article Polyunsaturated Fatty Acids and Their Correlations with Parameters of Oxidative/Antioxidant Potential of the Blood and Lipoprotein-Associated Phospholipase A2 in Coronary Atherosclerosis
- Authors: Shramko V.S.1, Polonskaya Y.V.1, Morozov S.V.2, Chernyak E.I.2, Chernyavsky A.M.3, Ragino Y.I.1
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Affiliations:
- Research Institute of Internal and Preventive Medicine, Affiliated Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
- E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
- Issue: Vol 166, No 1 (2018)
- Pages: 11-14
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240794
- DOI: https://doi.org/10.1007/s10517-018-4277-5
- ID: 240794
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Abstract
We studied serum content of some polyunsaturated fatty acids and their correlations with parameters of oxidative stress (FORT), antioxidant protection (FORD), lipoprotein-associated phospholipase A2 (LP-PLA2), and serum level of LPO products in male patients with coronary atherosclerosis. The mass fraction of polyunsaturated fatty acids and FORD were lower, while LP-PLA2, FORT, and concentration of LPO products were higher than in the control group (conventionally healthy men). Negative correlations of medium strength of polyunsaturated fatty acids with inflammation markers and oxidative stress were revealed, which can indicate that the decrease in polyunsaturated fatty acids content is associated with enhanced generation of free radicals, and consequently with increased risk of early atherosclerosis development.
About the authors
V. S. Shramko
Research Institute of Internal and Preventive Medicine, Affiliated Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Author for correspondence.
Email: nosova@211.ru
Russian Federation, Novosibirsk
YA. V. Polonskaya
Research Institute of Internal and Preventive Medicine, Affiliated Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: nosova@211.ru
Russian Federation, Novosibirsk
S. V. Morozov
N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: nosova@211.ru
Russian Federation, Novosibirsk
E. I. Chernyak
N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences
Email: nosova@211.ru
Russian Federation, Novosibirsk
A. M. Chernyavsky
E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Email: nosova@211.ru
Russian Federation, Novosibirsk
Yu. I. Ragino
Research Institute of Internal and Preventive Medicine, Affiliated Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: nosova@211.ru
Russian Federation, Novosibirsk
