Redox-Dependent Expression of Genes Encoding NADPH Oxidase 5 and the Key Antioxidant Enzymes during Formation of Drug Resistance of Tumor Cells to Cisplatin
- 作者: Kalinina E.1, Andreev Y.2, Petrova A.1, Lubova K.2, Shtil’ A.3, Chernov N.1, Novichkova M.1, Nurmuradov N.1
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隶属关系:
- Peoples’ Friendship University of Russia
- M. M. Shemyakin and Yu. A. Ovchinnikov of Institute of Bioorganic Chemistry, Russian Academy of Sciences
- N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
- 期: 卷 165, 编号 5 (2018)
- 页面: 678-681
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240660
- DOI: https://doi.org/10.1007/s10517-018-4240-5
- ID: 240660
如何引用文章
详细
Expression of genes that plays a significant role in the control of cellular redox homeostasis was studied during the development of drug resistance of human ovarian adenocarcinoma SKOV-3 cells to cisplatin. It was found that the development of drug resistance was accompanied by enhanced expression of the genes encoding the key antioxidant enzymes (SOD2, CAT, GPX1, and HO-1) and transcription factor Nrf2, as well as reduced expression of the gene encoding NOX5 isoform of NADPH oxidase. The results testify to redox-dependent development of the adaptive antioxidant response as an important process in the mechanism of formation of resistance to cisplatin.
作者简介
E. Kalinina
Peoples’ Friendship University of Russia
编辑信件的主要联系方式.
Email: elena.v.kalinina@gmail.com
俄罗斯联邦, Moscow
Y. Andreev
M. M. Shemyakin and Yu. A. Ovchinnikov of Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: elena.v.kalinina@gmail.com
俄罗斯联邦, Moscow
A. Petrova
Peoples’ Friendship University of Russia
Email: elena.v.kalinina@gmail.com
俄罗斯联邦, Moscow
K. Lubova
M. M. Shemyakin and Yu. A. Ovchinnikov of Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: elena.v.kalinina@gmail.com
俄罗斯联邦, Moscow
A. Shtil’
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
Email: elena.v.kalinina@gmail.com
俄罗斯联邦, Moscow
N. Chernov
Peoples’ Friendship University of Russia
Email: elena.v.kalinina@gmail.com
俄罗斯联邦, Moscow
M. Novichkova
Peoples’ Friendship University of Russia
Email: elena.v.kalinina@gmail.com
俄罗斯联邦, Moscow
N. Nurmuradov
Peoples’ Friendship University of Russia
Email: elena.v.kalinina@gmail.com
俄罗斯联邦, Moscow
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