Redox-Dependent Expression of Genes Encoding NADPH Oxidase 5 and the Key Antioxidant Enzymes during Formation of Drug Resistance of Tumor Cells to Cisplatin
- Авторлар: Kalinina E.1, Andreev Y.2, Petrova A.1, Lubova K.2, Shtil’ A.3, Chernov N.1, Novichkova M.1, Nurmuradov N.1
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Мекемелер:
- Peoples’ Friendship University of Russia
- M. M. Shemyakin and Yu. A. Ovchinnikov of Institute of Bioorganic Chemistry, Russian Academy of Sciences
- N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
- Шығарылым: Том 165, № 5 (2018)
- Беттер: 678-681
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240660
- DOI: https://doi.org/10.1007/s10517-018-4240-5
- ID: 240660
Дәйексөз келтіру
Аннотация
Expression of genes that plays a significant role in the control of cellular redox homeostasis was studied during the development of drug resistance of human ovarian adenocarcinoma SKOV-3 cells to cisplatin. It was found that the development of drug resistance was accompanied by enhanced expression of the genes encoding the key antioxidant enzymes (SOD2, CAT, GPX1, and HO-1) and transcription factor Nrf2, as well as reduced expression of the gene encoding NOX5 isoform of NADPH oxidase. The results testify to redox-dependent development of the adaptive antioxidant response as an important process in the mechanism of formation of resistance to cisplatin.
Авторлар туралы
E. Kalinina
Peoples’ Friendship University of Russia
Хат алмасуға жауапты Автор.
Email: elena.v.kalinina@gmail.com
Ресей, Moscow
Y. Andreev
M. M. Shemyakin and Yu. A. Ovchinnikov of Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: elena.v.kalinina@gmail.com
Ресей, Moscow
A. Petrova
Peoples’ Friendship University of Russia
Email: elena.v.kalinina@gmail.com
Ресей, Moscow
K. Lubova
M. M. Shemyakin and Yu. A. Ovchinnikov of Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: elena.v.kalinina@gmail.com
Ресей, Moscow
A. Shtil’
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
Email: elena.v.kalinina@gmail.com
Ресей, Moscow
N. Chernov
Peoples’ Friendship University of Russia
Email: elena.v.kalinina@gmail.com
Ресей, Moscow
M. Novichkova
Peoples’ Friendship University of Russia
Email: elena.v.kalinina@gmail.com
Ресей, Moscow
N. Nurmuradov
Peoples’ Friendship University of Russia
Email: elena.v.kalinina@gmail.com
Ресей, Moscow
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