Redox-Dependent Expression of Genes Encoding NADPH Oxidase 5 and the Key Antioxidant Enzymes during Formation of Drug Resistance of Tumor Cells to Cisplatin
- Autores: Kalinina E.1, Andreev Y.2, Petrova A.1, Lubova K.2, Shtil’ A.3, Chernov N.1, Novichkova M.1, Nurmuradov N.1
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Afiliações:
- Peoples’ Friendship University of Russia
- M. M. Shemyakin and Yu. A. Ovchinnikov of Institute of Bioorganic Chemistry, Russian Academy of Sciences
- N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
- Edição: Volume 165, Nº 5 (2018)
- Páginas: 678-681
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240660
- DOI: https://doi.org/10.1007/s10517-018-4240-5
- ID: 240660
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Resumo
Expression of genes that plays a significant role in the control of cellular redox homeostasis was studied during the development of drug resistance of human ovarian adenocarcinoma SKOV-3 cells to cisplatin. It was found that the development of drug resistance was accompanied by enhanced expression of the genes encoding the key antioxidant enzymes (SOD2, CAT, GPX1, and HO-1) and transcription factor Nrf2, as well as reduced expression of the gene encoding NOX5 isoform of NADPH oxidase. The results testify to redox-dependent development of the adaptive antioxidant response as an important process in the mechanism of formation of resistance to cisplatin.
Sobre autores
E. Kalinina
Peoples’ Friendship University of Russia
Autor responsável pela correspondência
Email: elena.v.kalinina@gmail.com
Rússia, Moscow
Y. Andreev
M. M. Shemyakin and Yu. A. Ovchinnikov of Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: elena.v.kalinina@gmail.com
Rússia, Moscow
A. Petrova
Peoples’ Friendship University of Russia
Email: elena.v.kalinina@gmail.com
Rússia, Moscow
K. Lubova
M. M. Shemyakin and Yu. A. Ovchinnikov of Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: elena.v.kalinina@gmail.com
Rússia, Moscow
A. Shtil’
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
Email: elena.v.kalinina@gmail.com
Rússia, Moscow
N. Chernov
Peoples’ Friendship University of Russia
Email: elena.v.kalinina@gmail.com
Rússia, Moscow
M. Novichkova
Peoples’ Friendship University of Russia
Email: elena.v.kalinina@gmail.com
Rússia, Moscow
N. Nurmuradov
Peoples’ Friendship University of Russia
Email: elena.v.kalinina@gmail.com
Rússia, Moscow