Effect of Metabolic Stress on Lysosomal Proteolysis in the Liver and Brain of Rats Receiving Q10-Enriched Ration


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Activation of lysosomal proteolysis and increased coenzyme Q10 level were revealed in the liver and brain of rats with individual typological features under conditions of food deprivation. Changes in cathepsin B activity in these tissues were different in behaviorally active and passive animals. We observed indirect modulating effect of coenzyme Q10 in the regulation of activity of lysosomal endopeptidases in the brain of animals with different behavior during adaptation to metabolic stress.

作者简介

N. Kirbaeva

Federal Research Center of Nutrition and Biotechnology, Russian Academy of Sciences

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Email: n.kirbaeva@gmail.com
俄罗斯联邦, Moscow

N. Sharanova

V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Email: n.kirbaeva@gmail.com
俄罗斯联邦, Moscow

V. Zhminchenko

Federal Research Center of Nutrition and Biotechnology, Russian Academy of Sciences

Email: n.kirbaeva@gmail.com
俄罗斯联邦, Moscow

A. Vasil’ev

Federal Research Center of Nutrition and Biotechnology, Russian Academy of Sciences

Email: n.kirbaeva@gmail.com
俄罗斯联邦, Moscow


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