Email this article Effect of Metabolic Stress on Lysosomal Proteolysis in the Liver and Brain of Rats Receiving Q10-Enriched Ration
- Authors: Kirbaeva N.V.1, Sharanova N.E.2, Zhminchenko V.M.1, Vasil’ev A.V.1
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Affiliations:
- Federal Research Center of Nutrition and Biotechnology, Russian Academy of Sciences
- V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
- Issue: Vol 165, No 3 (2018)
- Pages: 307-310
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240255
- DOI: https://doi.org/10.1007/s10517-018-4156-0
- ID: 240255
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Abstract
Activation of lysosomal proteolysis and increased coenzyme Q10 level were revealed in the liver and brain of rats with individual typological features under conditions of food deprivation. Changes in cathepsin B activity in these tissues were different in behaviorally active and passive animals. We observed indirect modulating effect of coenzyme Q10 in the regulation of activity of lysosomal endopeptidases in the brain of animals with different behavior during adaptation to metabolic stress.
About the authors
N. V. Kirbaeva
Federal Research Center of Nutrition and Biotechnology, Russian Academy of Sciences
Author for correspondence.
Email: n.kirbaeva@gmail.com
Russian Federation, Moscow
N. E. Sharanova
V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Email: n.kirbaeva@gmail.com
Russian Federation, Moscow
V. M. Zhminchenko
Federal Research Center of Nutrition and Biotechnology, Russian Academy of Sciences
Email: n.kirbaeva@gmail.com
Russian Federation, Moscow
A. V. Vasil’ev
Federal Research Center of Nutrition and Biotechnology, Russian Academy of Sciences
Email: n.kirbaeva@gmail.com
Russian Federation, Moscow
