In Vitro  Study of Antitumor Effect of Antimicrobial Peptide Tachyplesin I in Combination with Cisplatin

D. V. Kuzmin; A. A. Emel’yanova; M. B. Kalashnikova; P. V. Panteleev; T. V. Ovchinnikova

doi:10.1007/s10517-018-4134-6

In Vitro Study of Antitumor Effect of Antimicrobial Peptide Tachyplesin I in Combination with Cisplatin

作者: Kuzmin D.¹, Emel’yanova A.¹, Kalashnikova M.¹, Panteleev P.¹, Ovchinnikova T.¹
隶属关系:
1. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
期: 卷 165, 编号 2 (2018)
页面: 220-224
栏目: Pharmacology and Toxicology
URL: https://journals.rcsi.science/0007-4888/article/view/240179
DOI: https://doi.org/10.1007/s10517-018-4134-6
ID: 240179

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We studied combined effect of β-hairpin antimicrobial peptide tachyplesin I and cytotoxic agent cisplatin on tumor and normal human cell lines. MTT assay and flow cytometry showed that tachyplesin I selectively sensitized cancer cells to cisplatin in specified concentration ratios. In vitro experiments demonstrated that combined use of tachyplesin I and cisplatin allows decreasing the effective dose of the cytostatic thus reducing nonspecific toxicity.