In Vitro  Study of Antitumor Effect of Antimicrobial Peptide Tachyplesin I in Combination with Cisplatin

D. V. Kuzmin; A. A. Emel’yanova; M. B. Kalashnikova; P. V. Panteleev; T. V. Ovchinnikova

doi:10.1007/s10517-018-4134-6

In Vitro Study of Antitumor Effect of Antimicrobial Peptide Tachyplesin I in Combination with Cisplatin

Authors: Kuzmin D.V.¹, Emel’yanova A.A.¹, Kalashnikova M.B.¹, Panteleev P.V.¹, Ovchinnikova T.V.¹
Affiliations:
1. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Issue: Vol 165, No 2 (2018)
Pages: 220-224
Section: Pharmacology and Toxicology
URL: https://journals.rcsi.science/0007-4888/article/view/240179
DOI: https://doi.org/10.1007/s10517-018-4134-6
ID: 240179

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Abstract

We studied combined effect of β-hairpin antimicrobial peptide tachyplesin I and cytotoxic agent cisplatin on tumor and normal human cell lines. MTT assay and flow cytometry showed that tachyplesin I selectively sensitized cancer cells to cisplatin in specified concentration ratios. In vitro experiments demonstrated that combined use of tachyplesin I and cisplatin allows decreasing the effective dose of the cytostatic thus reducing nonspecific toxicity.