Therapeutic Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Neuroinflammation and Neuroplasticity in Patients with Parkinson’s Disease: a Placebo-Controlled Study
- 作者: Aftanas L.1,2, Gevorgyan M.1, Zhanaeva S.1, Dzemidovich S.1, Kulikova K.1, Al’perina E.1, Danilenko K.1,2, Idova G.1,2
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隶属关系:
- Research Institute of Physiology and Fundamental Medicine
- Novosibirsk National Research State University
- 期: 卷 165, 编号 2 (2018)
- 页面: 195-199
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240159
- DOI: https://doi.org/10.1007/s10517-018-4128-4
- ID: 240159
如何引用文章
详细
The parallel placebo-controlled study examined the therapeutic effects of dual-target repetitive transcranial magnetic stimulation (rTMS) of the motor cortex (bilaterally) and the left prefrontal cortex (dorsolaterally) on spontaneous and mitogen-stimulating synthesis of pro- and anti-inflammatory cytokines by the blood cells and the level of brain-derived neurotrophic factor (BDNF) in blood serum of patients with Parkinson’s disease. The significantly steeper positive clinical dynamics (assessed by UPRSD scale) observed in rTMS group in comparison with the placebo group was accompanied by a significant drop in spontaneous production of proinflammatory cytokines IFNγ and IL-17A. rTMS produced no significant effect on serum BDNF. The possible mechanisms of rTMS therapeutic action on the level of cytokines associated with neuroinflammation in patients with Parkinson’s disease are discussed.
作者简介
L. Aftanas
Research Institute of Physiology and Fundamental Medicine; Novosibirsk National Research State University
编辑信件的主要联系方式.
Email: liaftanas@gmail.com
俄罗斯联邦, Novosibirsk; Novosibirsk
M. Gevorgyan
Research Institute of Physiology and Fundamental Medicine
Email: liaftanas@gmail.com
俄罗斯联邦, Novosibirsk
S. Zhanaeva
Research Institute of Physiology and Fundamental Medicine
Email: liaftanas@gmail.com
俄罗斯联邦, Novosibirsk
S. Dzemidovich
Research Institute of Physiology and Fundamental Medicine
Email: liaftanas@gmail.com
俄罗斯联邦, Novosibirsk
K. Kulikova
Research Institute of Physiology and Fundamental Medicine
Email: liaftanas@gmail.com
俄罗斯联邦, Novosibirsk
E. Al’perina
Research Institute of Physiology and Fundamental Medicine
Email: liaftanas@gmail.com
俄罗斯联邦, Novosibirsk
K. Danilenko
Research Institute of Physiology and Fundamental Medicine; Novosibirsk National Research State University
Email: liaftanas@gmail.com
俄罗斯联邦, Novosibirsk; Novosibirsk
G. Idova
Research Institute of Physiology and Fundamental Medicine; Novosibirsk National Research State University
Email: liaftanas@gmail.com
俄罗斯联邦, Novosibirsk; Novosibirsk