Therapeutic Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Neuroinflammation and Neuroplasticity in Patients with Parkinson’s Disease: a Placebo-Controlled Study
- Авторы: Aftanas L.1,2, Gevorgyan M.1, Zhanaeva S.1, Dzemidovich S.1, Kulikova K.1, Al’perina E.1, Danilenko K.1,2, Idova G.1,2
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Учреждения:
- Research Institute of Physiology and Fundamental Medicine
- Novosibirsk National Research State University
- Выпуск: Том 165, № 2 (2018)
- Страницы: 195-199
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240159
- DOI: https://doi.org/10.1007/s10517-018-4128-4
- ID: 240159
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Аннотация
The parallel placebo-controlled study examined the therapeutic effects of dual-target repetitive transcranial magnetic stimulation (rTMS) of the motor cortex (bilaterally) and the left prefrontal cortex (dorsolaterally) on spontaneous and mitogen-stimulating synthesis of pro- and anti-inflammatory cytokines by the blood cells and the level of brain-derived neurotrophic factor (BDNF) in blood serum of patients with Parkinson’s disease. The significantly steeper positive clinical dynamics (assessed by UPRSD scale) observed in rTMS group in comparison with the placebo group was accompanied by a significant drop in spontaneous production of proinflammatory cytokines IFNγ and IL-17A. rTMS produced no significant effect on serum BDNF. The possible mechanisms of rTMS therapeutic action on the level of cytokines associated with neuroinflammation in patients with Parkinson’s disease are discussed.
Об авторах
L. Aftanas
Research Institute of Physiology and Fundamental Medicine; Novosibirsk National Research State University
Автор, ответственный за переписку.
Email: liaftanas@gmail.com
Россия, Novosibirsk; Novosibirsk
M. Gevorgyan
Research Institute of Physiology and Fundamental Medicine
Email: liaftanas@gmail.com
Россия, Novosibirsk
S. Zhanaeva
Research Institute of Physiology and Fundamental Medicine
Email: liaftanas@gmail.com
Россия, Novosibirsk
S. Dzemidovich
Research Institute of Physiology and Fundamental Medicine
Email: liaftanas@gmail.com
Россия, Novosibirsk
K. Kulikova
Research Institute of Physiology and Fundamental Medicine
Email: liaftanas@gmail.com
Россия, Novosibirsk
E. Al’perina
Research Institute of Physiology and Fundamental Medicine
Email: liaftanas@gmail.com
Россия, Novosibirsk
K. Danilenko
Research Institute of Physiology and Fundamental Medicine; Novosibirsk National Research State University
Email: liaftanas@gmail.com
Россия, Novosibirsk; Novosibirsk
G. Idova
Research Institute of Physiology and Fundamental Medicine; Novosibirsk National Research State University
Email: liaftanas@gmail.com
Россия, Novosibirsk; Novosibirsk