Therapeutic Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Neuroinflammation and Neuroplasticity in Patients with Parkinson’s Disease: a Placebo-Controlled Study
- Autores: Aftanas L.1,2, Gevorgyan M.1, Zhanaeva S.1, Dzemidovich S.1, Kulikova K.1, Al’perina E.1, Danilenko K.1,2, Idova G.1,2
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Afiliações:
- Research Institute of Physiology and Fundamental Medicine
- Novosibirsk National Research State University
- Edição: Volume 165, Nº 2 (2018)
- Páginas: 195-199
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240159
- DOI: https://doi.org/10.1007/s10517-018-4128-4
- ID: 240159
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Resumo
The parallel placebo-controlled study examined the therapeutic effects of dual-target repetitive transcranial magnetic stimulation (rTMS) of the motor cortex (bilaterally) and the left prefrontal cortex (dorsolaterally) on spontaneous and mitogen-stimulating synthesis of pro- and anti-inflammatory cytokines by the blood cells and the level of brain-derived neurotrophic factor (BDNF) in blood serum of patients with Parkinson’s disease. The significantly steeper positive clinical dynamics (assessed by UPRSD scale) observed in rTMS group in comparison with the placebo group was accompanied by a significant drop in spontaneous production of proinflammatory cytokines IFNγ and IL-17A. rTMS produced no significant effect on serum BDNF. The possible mechanisms of rTMS therapeutic action on the level of cytokines associated with neuroinflammation in patients with Parkinson’s disease are discussed.
Sobre autores
L. Aftanas
Research Institute of Physiology and Fundamental Medicine; Novosibirsk National Research State University
Autor responsável pela correspondência
Email: liaftanas@gmail.com
Rússia, Novosibirsk; Novosibirsk
M. Gevorgyan
Research Institute of Physiology and Fundamental Medicine
Email: liaftanas@gmail.com
Rússia, Novosibirsk
S. Zhanaeva
Research Institute of Physiology and Fundamental Medicine
Email: liaftanas@gmail.com
Rússia, Novosibirsk
S. Dzemidovich
Research Institute of Physiology and Fundamental Medicine
Email: liaftanas@gmail.com
Rússia, Novosibirsk
K. Kulikova
Research Institute of Physiology and Fundamental Medicine
Email: liaftanas@gmail.com
Rússia, Novosibirsk
E. Al’perina
Research Institute of Physiology and Fundamental Medicine
Email: liaftanas@gmail.com
Rússia, Novosibirsk
K. Danilenko
Research Institute of Physiology and Fundamental Medicine; Novosibirsk National Research State University
Email: liaftanas@gmail.com
Rússia, Novosibirsk; Novosibirsk
G. Idova
Research Institute of Physiology and Fundamental Medicine; Novosibirsk National Research State University
Email: liaftanas@gmail.com
Rússia, Novosibirsk; Novosibirsk