Use of Mesenchymal Stem Cells for Possible Repair of Doxorubicin-Damaged Organs and Tissues in Experimental Monkeys
- 作者: Agrba V.1, Karal-Ogly D.1, Gvozdik T.1, Kaplanyan P.1, Demenkova N.1, Gvaramiya I.1, Mukhametzyanova E.1, Shamsutdinova O.1, Chuguev Y.1, Kal’sina S.1, Konoplyannikov A.1, Araviashvili D.1, Klots I.1, Lapin B.1
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隶属关系:
- Research Institute of Medical Primatology
- 期: 卷 165, 编号 1 (2018)
- 页面: 101-104
- 栏目: Primatology
- URL: https://journals.rcsi.science/0007-4888/article/view/240027
- DOI: https://doi.org/10.1007/s10517-018-4108-8
- ID: 240027
如何引用文章
详细
Three injections of doxorubicin to rhesus macaques cause severe intoxication, characterized by anemia, cachexia, and degeneration of the viscera. The life span of monkeys injected with the drug and receiving after 24 h mesenchymal stem cell transplantation varied from 96 to 120 days in comparison with 50-74 days in animals receiving stem cells before doxorubicin. Controls received doxorubicin and saline; the lifespan of one monkey was 24 days, of the other — 1 year and 8 months. The increase in activity of proinflammatory cytokine IL-6 was paralleled by an increase in the level of C-reactive protein.
作者简介
V. Agrba
Research Institute of Medical Primatology
编辑信件的主要联系方式.
Email: agrba_vz@mail.ru
俄罗斯联邦, Sochi
D. Karal-Ogly
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
俄罗斯联邦, Sochi
T. Gvozdik
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
俄罗斯联邦, Sochi
P. Kaplanyan
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
俄罗斯联邦, Sochi
N. Demenkova
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
俄罗斯联邦, Sochi
I. Gvaramiya
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
俄罗斯联邦, Sochi
E. Mukhametzyanova
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
俄罗斯联邦, Sochi
O. Shamsutdinova
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
俄罗斯联邦, Sochi
Yu. Chuguev
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
俄罗斯联邦, Sochi
S. Kal’sina
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
俄罗斯联邦, Sochi
A. Konoplyannikov
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
俄罗斯联邦, Sochi
D. Araviashvili
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
俄罗斯联邦, Sochi
I. Klots
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
俄罗斯联邦, Sochi
B. Lapin
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
俄罗斯联邦, Sochi