Use of Mesenchymal Stem Cells for Possible Repair of Doxorubicin-Damaged Organs and Tissues in Experimental Monkeys
- Authors: Agrba V.Z.1, Karal-Ogly D.D.1, Gvozdik T.E.1, Kaplanyan P.A.1, Demenkova N.P.1, Gvaramiya I.A.1, Mukhametzyanova E.I.1, Shamsutdinova O.A.1, Chuguev Y.P.1, Kal’sina S.S.1, Konoplyannikov A.G.1, Araviashvili D.E.1, Klots I.N.1, Lapin B.A.1
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Affiliations:
- Research Institute of Medical Primatology
- Issue: Vol 165, No 1 (2018)
- Pages: 101-104
- Section: Primatology
- URL: https://journals.rcsi.science/0007-4888/article/view/240027
- DOI: https://doi.org/10.1007/s10517-018-4108-8
- ID: 240027
Cite item
Abstract
Three injections of doxorubicin to rhesus macaques cause severe intoxication, characterized by anemia, cachexia, and degeneration of the viscera. The life span of monkeys injected with the drug and receiving after 24 h mesenchymal stem cell transplantation varied from 96 to 120 days in comparison with 50-74 days in animals receiving stem cells before doxorubicin. Controls received doxorubicin and saline; the lifespan of one monkey was 24 days, of the other — 1 year and 8 months. The increase in activity of proinflammatory cytokine IL-6 was paralleled by an increase in the level of C-reactive protein.
About the authors
V. Z. Agrba
Research Institute of Medical Primatology
Author for correspondence.
Email: agrba_vz@mail.ru
Russian Federation, Sochi
D. D. Karal-Ogly
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Russian Federation, Sochi
T. E. Gvozdik
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Russian Federation, Sochi
P. A. Kaplanyan
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Russian Federation, Sochi
N. P. Demenkova
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Russian Federation, Sochi
I. A. Gvaramiya
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Russian Federation, Sochi
E. I. Mukhametzyanova
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Russian Federation, Sochi
O. A. Shamsutdinova
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Russian Federation, Sochi
Yu. P. Chuguev
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Russian Federation, Sochi
S. Sh. Kal’sina
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Russian Federation, Sochi
A. G. Konoplyannikov
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Russian Federation, Sochi
D. E. Araviashvili
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Russian Federation, Sochi
I. N. Klots
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Russian Federation, Sochi
B. A. Lapin
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Russian Federation, Sochi