Use of Mesenchymal Stem Cells for Possible Repair of Doxorubicin-Damaged Organs and Tissues in Experimental Monkeys
- Авторлар: Agrba V.1, Karal-Ogly D.1, Gvozdik T.1, Kaplanyan P.1, Demenkova N.1, Gvaramiya I.1, Mukhametzyanova E.1, Shamsutdinova O.1, Chuguev Y.1, Kal’sina S.1, Konoplyannikov A.1, Araviashvili D.1, Klots I.1, Lapin B.1
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Мекемелер:
- Research Institute of Medical Primatology
- Шығарылым: Том 165, № 1 (2018)
- Беттер: 101-104
- Бөлім: Primatology
- URL: https://journals.rcsi.science/0007-4888/article/view/240027
- DOI: https://doi.org/10.1007/s10517-018-4108-8
- ID: 240027
Дәйексөз келтіру
Аннотация
Three injections of doxorubicin to rhesus macaques cause severe intoxication, characterized by anemia, cachexia, and degeneration of the viscera. The life span of monkeys injected with the drug and receiving after 24 h mesenchymal stem cell transplantation varied from 96 to 120 days in comparison with 50-74 days in animals receiving stem cells before doxorubicin. Controls received doxorubicin and saline; the lifespan of one monkey was 24 days, of the other — 1 year and 8 months. The increase in activity of proinflammatory cytokine IL-6 was paralleled by an increase in the level of C-reactive protein.
Авторлар туралы
V. Agrba
Research Institute of Medical Primatology
Хат алмасуға жауапты Автор.
Email: agrba_vz@mail.ru
Ресей, Sochi
D. Karal-Ogly
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Ресей, Sochi
T. Gvozdik
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Ресей, Sochi
P. Kaplanyan
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Ресей, Sochi
N. Demenkova
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Ресей, Sochi
I. Gvaramiya
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Ресей, Sochi
E. Mukhametzyanova
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Ресей, Sochi
O. Shamsutdinova
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Ресей, Sochi
Yu. Chuguev
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Ресей, Sochi
S. Kal’sina
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Ресей, Sochi
A. Konoplyannikov
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Ресей, Sochi
D. Araviashvili
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Ресей, Sochi
I. Klots
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Ресей, Sochi
B. Lapin
Research Institute of Medical Primatology
Email: agrba_vz@mail.ru
Ресей, Sochi