Polymorphism of Oprm1 Gene and Its Association with Manifestations of N-(1-Phenethyl-4-Piperidyl)Propionanilide Intoxication in Rats
- 作者: Varlamova O.1, Babkin A.1, Berdinskikh I.1, Nazarov G.1, Nikiforov A.1, Bykov V.1, Ivanov M.2
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隶属关系:
- State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
- Institute of Toxicology, Federal Medical-Biological Agency of Russia
- 期: 卷 165, 编号 1 (2018)
- 页面: 72-74
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239987
- DOI: https://doi.org/10.1007/s10517-018-4102-1
- ID: 239987
如何引用文章
详细
We studied association of Oprm1 gene polymorphisms with signs of N-(1-phenethyl-4-piperidyl)propionanilide intoxication in rats. It was found that the rate of intoxication in laboratory animals depends on genetic features. A polymorphic variant rs105312806 of Oprm1 gene can be a possible marker of animal sensitivity to opioid receptor agonists. This hypothesis was supported by differences in the rats of intoxication signs such as time to lateral posture and sleep duration in homozygous rats carrying different alleles. In rats with AA genotype, the time to lateral posture was shorter by 1.3 times and sleep duration was longer by 3.5 times than in carriers of GG genotype.
作者简介
O. Varlamova
State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: nikiforov2004@mail.ru
俄罗斯联邦, Moscow
A. Babkin
State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: nikiforov2004@mail.ru
俄罗斯联邦, Moscow
I. Berdinskikh
State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: nikiforov2004@mail.ru
俄罗斯联邦, Moscow
G. Nazarov
State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: nikiforov2004@mail.ru
俄罗斯联邦, Moscow
A. Nikiforov
State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
编辑信件的主要联系方式.
Email: nikiforov2004@mail.ru
俄罗斯联邦, Moscow
V. Bykov
State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: nikiforov2004@mail.ru
俄罗斯联邦, Moscow
M. Ivanov
Institute of Toxicology, Federal Medical-Biological Agency of Russia
Email: nikiforov2004@mail.ru
俄罗斯联邦, St. Petersburg