Polymorphism of Oprm1 Gene and Its Association with Manifestations of N-(1-Phenethyl-4-Piperidyl)Propionanilide Intoxication in Rats
- Autores: Varlamova O.1, Babkin A.1, Berdinskikh I.1, Nazarov G.1, Nikiforov A.1, Bykov V.1, Ivanov M.2
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Afiliações:
- State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
- Institute of Toxicology, Federal Medical-Biological Agency of Russia
- Edição: Volume 165, Nº 1 (2018)
- Páginas: 72-74
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239987
- DOI: https://doi.org/10.1007/s10517-018-4102-1
- ID: 239987
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Resumo
We studied association of Oprm1 gene polymorphisms with signs of N-(1-phenethyl-4-piperidyl)propionanilide intoxication in rats. It was found that the rate of intoxication in laboratory animals depends on genetic features. A polymorphic variant rs105312806 of Oprm1 gene can be a possible marker of animal sensitivity to opioid receptor agonists. This hypothesis was supported by differences in the rats of intoxication signs such as time to lateral posture and sleep duration in homozygous rats carrying different alleles. In rats with AA genotype, the time to lateral posture was shorter by 1.3 times and sleep duration was longer by 3.5 times than in carriers of GG genotype.
Sobre autores
O. Varlamova
State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: nikiforov2004@mail.ru
Rússia, Moscow
A. Babkin
State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: nikiforov2004@mail.ru
Rússia, Moscow
I. Berdinskikh
State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: nikiforov2004@mail.ru
Rússia, Moscow
G. Nazarov
State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: nikiforov2004@mail.ru
Rússia, Moscow
A. Nikiforov
State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Autor responsável pela correspondência
Email: nikiforov2004@mail.ru
Rússia, Moscow
V. Bykov
State Research and Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: nikiforov2004@mail.ru
Rússia, Moscow
M. Ivanov
Institute of Toxicology, Federal Medical-Biological Agency of Russia
Email: nikiforov2004@mail.ru
Rússia, St. Petersburg
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