Pathological Remodeling of the Myocardium in Chronic Heart Failure: Role of PGC-1α
- 作者: Kulikova T.1, Stepanova O.1, Voronova A.1, Valikhov M.1, Sirotkin V.1, Zhirov I.1, Tereshchenko S.1, Masenko V.1, Samko A.1, Sukhikh G.2
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隶属关系:
- National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
- V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- 期: 卷 164, 编号 6 (2018)
- 页面: 794-797
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239919
- DOI: https://doi.org/10.1007/s10517-018-4082-1
- ID: 239919
如何引用文章
详细
Pathological remodeling of the myocardium in chronic heart failure includes the development of pathological cardiac hypertrophy, reactivation of the fetal genetic program, and disorders in cardiac energy metabolism. Coactivator-1α of receptor γ activated by peroxisome proliferator (PGC-1α), a transcription coactivator of nuclear receptors and metabolism master regulator, plays an important role in cardiac metabolism regulation. Studies on the animals models of chronic heart failure have demonstrated the development of pathological cardiac hypertrophy, metabolic disorders, and reactivation of the fetal genetic program; these processes are mutually related. An important role in regulation of these processes belongs to PGC-1α; its low expression indicates low activity and down-regulation of this coactivator. Pathological cardiac hypertrophy, decrease of PGC-1α activity, and reactivation of the fetal genetic program in chronic heart failure are demonstrated.
作者简介
T. Kulikova
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: kulikoffak@mail.ru
俄罗斯联邦, Moscow
O. Stepanova
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
俄罗斯联邦, Moscow
A. Voronova
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
俄罗斯联邦, Moscow
M. Valikhov
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
俄罗斯联邦, Moscow
V. Sirotkin
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
俄罗斯联邦, Moscow
I. Zhirov
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
俄罗斯联邦, Moscow
S. Tereshchenko
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
俄罗斯联邦, Moscow
V. Masenko
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
俄罗斯联邦, Moscow
A. Samko
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
俄罗斯联邦, Moscow
G. Sukhikh
V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
俄罗斯联邦, Moscow
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