Pathological Remodeling of the Myocardium in Chronic Heart Failure: Role of PGC-1α
- Authors: Kulikova T.G.1, Stepanova O.V.1, Voronova A.D.1, Valikhov M.P.1, Sirotkin V.N.1, Zhirov I.V.1, Tereshchenko S.N.1, Masenko V.P.1, Samko A.N.1, Sukhikh G.T.2
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Affiliations:
- National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
- V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- Issue: Vol 164, No 6 (2018)
- Pages: 794-797
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239919
- DOI: https://doi.org/10.1007/s10517-018-4082-1
- ID: 239919
Cite item
Abstract
Pathological remodeling of the myocardium in chronic heart failure includes the development of pathological cardiac hypertrophy, reactivation of the fetal genetic program, and disorders in cardiac energy metabolism. Coactivator-1α of receptor γ activated by peroxisome proliferator (PGC-1α), a transcription coactivator of nuclear receptors and metabolism master regulator, plays an important role in cardiac metabolism regulation. Studies on the animals models of chronic heart failure have demonstrated the development of pathological cardiac hypertrophy, metabolic disorders, and reactivation of the fetal genetic program; these processes are mutually related. An important role in regulation of these processes belongs to PGC-1α; its low expression indicates low activity and down-regulation of this coactivator. Pathological cardiac hypertrophy, decrease of PGC-1α activity, and reactivation of the fetal genetic program in chronic heart failure are demonstrated.
About the authors
T. G. Kulikova
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: kulikoffak@mail.ru
Russian Federation, Moscow
O. V. Stepanova
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
Russian Federation, Moscow
A. D. Voronova
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
Russian Federation, Moscow
M. P. Valikhov
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
Russian Federation, Moscow
V. N. Sirotkin
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
Russian Federation, Moscow
I. V. Zhirov
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
Russian Federation, Moscow
S. N. Tereshchenko
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
Russian Federation, Moscow
V. P. Masenko
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
Russian Federation, Moscow
A. N. Samko
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
Russian Federation, Moscow
G. T. Sukhikh
V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
Russian Federation, Moscow