Pathological Remodeling of the Myocardium in Chronic Heart Failure: Role of PGC-1α
- Авторы: Kulikova T.1, Stepanova O.1, Voronova A.1, Valikhov M.1, Sirotkin V.1, Zhirov I.1, Tereshchenko S.1, Masenko V.1, Samko A.1, Sukhikh G.2
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Учреждения:
- National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
- V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- Выпуск: Том 164, № 6 (2018)
- Страницы: 794-797
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239919
- DOI: https://doi.org/10.1007/s10517-018-4082-1
- ID: 239919
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Аннотация
Pathological remodeling of the myocardium in chronic heart failure includes the development of pathological cardiac hypertrophy, reactivation of the fetal genetic program, and disorders in cardiac energy metabolism. Coactivator-1α of receptor γ activated by peroxisome proliferator (PGC-1α), a transcription coactivator of nuclear receptors and metabolism master regulator, plays an important role in cardiac metabolism regulation. Studies on the animals models of chronic heart failure have demonstrated the development of pathological cardiac hypertrophy, metabolic disorders, and reactivation of the fetal genetic program; these processes are mutually related. An important role in regulation of these processes belongs to PGC-1α; its low expression indicates low activity and down-regulation of this coactivator. Pathological cardiac hypertrophy, decrease of PGC-1α activity, and reactivation of the fetal genetic program in chronic heart failure are demonstrated.
Об авторах
T. Kulikova
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: kulikoffak@mail.ru
Россия, Moscow
O. Stepanova
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
Россия, Moscow
A. Voronova
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
Россия, Moscow
M. Valikhov
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
Россия, Moscow
V. Sirotkin
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
Россия, Moscow
I. Zhirov
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
Россия, Moscow
S. Tereshchenko
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
Россия, Moscow
V. Masenko
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
Россия, Moscow
A. Samko
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
Россия, Moscow
G. Sukhikh
V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: kulikoffak@mail.ru
Россия, Moscow