Induced Pluripotent Stem Cell-Derived Hematopoietic Embryoid Bodies Secrete Sphingosine-1-Phosphate and Revert Endothelial Injury
- 作者: Kasuda S.1, Kudo R.1, Yuui K.1, Sakurai Y.2, Hatake K.1
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隶属关系:
- Department of Legal Medicine, Nara Medical University
- Department of Pediatrics, Matsubara Tokushukai Hospital
- 期: 卷 164, 编号 6 (2018)
- 页面: 775-779
- 栏目: Experimental Methods for Clinical Practice
- URL: https://journals.rcsi.science/0007-4888/article/view/239906
- DOI: https://doi.org/10.1007/s10517-018-4078-x
- ID: 239906
如何引用文章
详细
The possibility of sphingosine-1-phosphate production by induced pluripotent stem cells is examined to assess their potential in treatment of sepsis. The hematopoietic embryoid bodies were derived from the culture of 6-day-old differentiated induced pluripotent stem cells. These embryoid bodies secreted sphingosine-1-phosphate, an important bioactive lipid that regulates integrity of the pulmonary endothelial barrier, prevents elevation of its permeability, and impedes the formation of stress fibers in human endotheliocytes derived from umbilical vein. The data attest to potentiality of induced pluripotent stem cells in treatment of sepsis.
作者简介
S. Kasuda
Department of Legal Medicine, Nara Medical University
编辑信件的主要联系方式.
Email: skasuda@naramed-u.ac.jp
日本, Kashihara, Nara
R. Kudo
Department of Legal Medicine, Nara Medical University
Email: skasuda@naramed-u.ac.jp
日本, Kashihara, Nara
K. Yuui
Department of Legal Medicine, Nara Medical University
Email: skasuda@naramed-u.ac.jp
日本, Kashihara, Nara
Y. Sakurai
Department of Pediatrics, Matsubara Tokushukai Hospital
Email: skasuda@naramed-u.ac.jp
日本, Matsubara, Osaka
K. Hatake
Department of Legal Medicine, Nara Medical University
Email: skasuda@naramed-u.ac.jp
日本, Kashihara, Nara
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