Induced Pluripotent Stem Cell-Derived Hematopoietic Embryoid Bodies Secrete Sphingosine-1-Phosphate and Revert Endothelial Injury
- Autores: Kasuda S.1, Kudo R.1, Yuui K.1, Sakurai Y.2, Hatake K.1
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Afiliações:
- Department of Legal Medicine, Nara Medical University
- Department of Pediatrics, Matsubara Tokushukai Hospital
- Edição: Volume 164, Nº 6 (2018)
- Páginas: 775-779
- Seção: Experimental Methods for Clinical Practice
- URL: https://journals.rcsi.science/0007-4888/article/view/239906
- DOI: https://doi.org/10.1007/s10517-018-4078-x
- ID: 239906
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Resumo
The possibility of sphingosine-1-phosphate production by induced pluripotent stem cells is examined to assess their potential in treatment of sepsis. The hematopoietic embryoid bodies were derived from the culture of 6-day-old differentiated induced pluripotent stem cells. These embryoid bodies secreted sphingosine-1-phosphate, an important bioactive lipid that regulates integrity of the pulmonary endothelial barrier, prevents elevation of its permeability, and impedes the formation of stress fibers in human endotheliocytes derived from umbilical vein. The data attest to potentiality of induced pluripotent stem cells in treatment of sepsis.
Sobre autores
S. Kasuda
Department of Legal Medicine, Nara Medical University
Autor responsável pela correspondência
Email: skasuda@naramed-u.ac.jp
Japão, Kashihara, Nara
R. Kudo
Department of Legal Medicine, Nara Medical University
Email: skasuda@naramed-u.ac.jp
Japão, Kashihara, Nara
K. Yuui
Department of Legal Medicine, Nara Medical University
Email: skasuda@naramed-u.ac.jp
Japão, Kashihara, Nara
Y. Sakurai
Department of Pediatrics, Matsubara Tokushukai Hospital
Email: skasuda@naramed-u.ac.jp
Japão, Matsubara, Osaka
K. Hatake
Department of Legal Medicine, Nara Medical University
Email: skasuda@naramed-u.ac.jp
Japão, Kashihara, Nara