Induced Pluripotent Stem Cell-Derived Hematopoietic Embryoid Bodies Secrete Sphingosine-1-Phosphate and Revert Endothelial Injury
- Авторлар: Kasuda S.1, Kudo R.1, Yuui K.1, Sakurai Y.2, Hatake K.1
-
Мекемелер:
- Department of Legal Medicine, Nara Medical University
- Department of Pediatrics, Matsubara Tokushukai Hospital
- Шығарылым: Том 164, № 6 (2018)
- Беттер: 775-779
- Бөлім: Experimental Methods for Clinical Practice
- URL: https://journals.rcsi.science/0007-4888/article/view/239906
- DOI: https://doi.org/10.1007/s10517-018-4078-x
- ID: 239906
Дәйексөз келтіру
Аннотация
The possibility of sphingosine-1-phosphate production by induced pluripotent stem cells is examined to assess their potential in treatment of sepsis. The hematopoietic embryoid bodies were derived from the culture of 6-day-old differentiated induced pluripotent stem cells. These embryoid bodies secreted sphingosine-1-phosphate, an important bioactive lipid that regulates integrity of the pulmonary endothelial barrier, prevents elevation of its permeability, and impedes the formation of stress fibers in human endotheliocytes derived from umbilical vein. The data attest to potentiality of induced pluripotent stem cells in treatment of sepsis.
Авторлар туралы
S. Kasuda
Department of Legal Medicine, Nara Medical University
Хат алмасуға жауапты Автор.
Email: skasuda@naramed-u.ac.jp
Жапония, Kashihara, Nara
R. Kudo
Department of Legal Medicine, Nara Medical University
Email: skasuda@naramed-u.ac.jp
Жапония, Kashihara, Nara
K. Yuui
Department of Legal Medicine, Nara Medical University
Email: skasuda@naramed-u.ac.jp
Жапония, Kashihara, Nara
Y. Sakurai
Department of Pediatrics, Matsubara Tokushukai Hospital
Email: skasuda@naramed-u.ac.jp
Жапония, Matsubara, Osaka
K. Hatake
Department of Legal Medicine, Nara Medical University
Email: skasuda@naramed-u.ac.jp
Жапония, Kashihara, Nara