Effect of Nanocrystalline Particles of Chitin on Blood Components in Humans and Experimental Animals
- 作者: Drozd N.1, Torlopov M.2, Udoratina E.2, Logvinova Y.1
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隶属关系:
- Hematology Research Center, Ministry of Health of the Russian Federation
- Institute of Chemistry of Komi Research Center, Ural Division of Russian Academy of Science
- 期: 卷 164, 编号 6 (2018)
- 页面: 766-769
- 栏目: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/239903
- DOI: https://doi.org/10.1007/s10517-018-4076-z
- ID: 239903
如何引用文章
详细
Nanocrystalline particles of chitin in the form of hydrosol in a concentration of 0.63 mg/ml have no effect on aggregation of human platelets and clotting time of platelet-poor plasma in coagulation tests. ADP-induced aggregation of human platelets was inhibited by these nanoparticles in concentrations of 0.63 and 1.00 mg/ml in comparison with the control. Intravenous administration of nanoparticles in a dose of 1 mg/kg to guinea pigs produced no anticoagulant effect. The nanocrystalline particles of chitin can be of interest as potential drug delivery systems.
作者简介
N. Drozd
Hematology Research Center, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: nndrozd@mail.ru
俄罗斯联邦, Moscow
M. Torlopov
Institute of Chemistry of Komi Research Center, Ural Division of Russian Academy of Science
Email: nndrozd@mail.ru
俄罗斯联邦, Syktyvkar, Republic of Komi
E. Udoratina
Institute of Chemistry of Komi Research Center, Ural Division of Russian Academy of Science
Email: nndrozd@mail.ru
俄罗斯联邦, Syktyvkar, Republic of Komi
Yu. Logvinova
Hematology Research Center, Ministry of Health of the Russian Federation
Email: nndrozd@mail.ru
俄罗斯联邦, Moscow