Email this article Effect of Nanocrystalline Particles of Chitin on Blood Components in Humans and Experimental Animals
- Authors: Drozd N.N.1, Torlopov M.A.2, Udoratina E.V.2, Logvinova Y.S.1
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Affiliations:
- Hematology Research Center, Ministry of Health of the Russian Federation
- Institute of Chemistry of Komi Research Center, Ural Division of Russian Academy of Science
- Issue: Vol 164, No 6 (2018)
- Pages: 766-769
- Section: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/239903
- DOI: https://doi.org/10.1007/s10517-018-4076-z
- ID: 239903
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Abstract
Nanocrystalline particles of chitin in the form of hydrosol in a concentration of 0.63 mg/ml have no effect on aggregation of human platelets and clotting time of platelet-poor plasma in coagulation tests. ADP-induced aggregation of human platelets was inhibited by these nanoparticles in concentrations of 0.63 and 1.00 mg/ml in comparison with the control. Intravenous administration of nanoparticles in a dose of 1 mg/kg to guinea pigs produced no anticoagulant effect. The nanocrystalline particles of chitin can be of interest as potential drug delivery systems.
About the authors
N. N. Drozd
Hematology Research Center, Ministry of Health of the Russian Federation
Author for correspondence.
Email: nndrozd@mail.ru
Russian Federation, Moscow
M. A. Torlopov
Institute of Chemistry of Komi Research Center, Ural Division of Russian Academy of Science
Email: nndrozd@mail.ru
Russian Federation, Syktyvkar, Republic of Komi
E. V. Udoratina
Institute of Chemistry of Komi Research Center, Ural Division of Russian Academy of Science
Email: nndrozd@mail.ru
Russian Federation, Syktyvkar, Republic of Komi
Yu. S. Logvinova
Hematology Research Center, Ministry of Health of the Russian Federation
Email: nndrozd@mail.ru
Russian Federation, Moscow
