Effect of Neoadjuvant Chemoradiation Therapy on Proteasome Pool in Rectal Cancer
- 作者: Astakhova T.1, Ivanova E.2, Rodoman G.3, Sumedi I.3, Afanas’ev S.2, Goncharov A.3, Kondakova I.2, Sharova N.1
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隶属关系:
- N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences
- Tomsk National Research Medical Center, Russian Academy of Sciences
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- 期: 卷 164, 编号 2 (2017)
- 页面: 191-194
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239470
- DOI: https://doi.org/10.1007/s10517-017-3955-z
- ID: 239470
如何引用文章
详细
In untreated rectal cancer patients, the chymotrypsin-like activity of proteasomes in tumor tissue was 3-fold higher than that in conventionally normal tissue, which is explained by up-regulation of expression of immunoproteasomes and total pool of proteasomes. After neoadjuvant chemoradiation therapy, expressions of the total pool of proteasomes and immunoproteasomes in the tumor as well as the relative ratios of these indices to those in conventionally normal tissue were smaller by 1.4-3.3 times in comparison with the untreated patients. These changes were paralleled with pronounced (4.5-fold) down-regulation of proteasome activity in the tumor and a 3.7-fold decrease of activity ratio for the proteasomes in tumor and in conventionally normal tissue. The number of immunoproteasome subunits and the chymotrypsin-like activity of proteasomes can be viewed as potential markers to prognosticate effectiveness of neoadjuvant chemoradiation therapy in rectal cancer patients.
作者简介
T. Astakhova
N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences
Email: npsharova@bk.ru
俄罗斯联邦, Moscow
E. Ivanova
Tomsk National Research Medical Center, Russian Academy of Sciences
Email: npsharova@bk.ru
俄罗斯联邦, Tomsk
G. Rodoman
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: npsharova@bk.ru
俄罗斯联邦, Moscow
I. Sumedi
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: npsharova@bk.ru
俄罗斯联邦, Moscow
S. Afanas’ev
Tomsk National Research Medical Center, Russian Academy of Sciences
Email: npsharova@bk.ru
俄罗斯联邦, Tomsk
A. Goncharov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: npsharova@bk.ru
俄罗斯联邦, Moscow
I. Kondakova
Tomsk National Research Medical Center, Russian Academy of Sciences
Email: npsharova@bk.ru
俄罗斯联邦, Tomsk
N. Sharova
N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: npsharova@bk.ru
俄罗斯联邦, Moscow
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