Effect of Neoadjuvant Chemoradiation Therapy on Proteasome Pool in Rectal Cancer
- Authors: Astakhova T.M.1, Ivanova E.V.2, Rodoman G.V.3, Sumedi I.R.3, Afanas’ev S.G.2, Goncharov A.L.3, Kondakova I.V.2, Sharova N.P.1
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Affiliations:
- N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences
- Tomsk National Research Medical Center, Russian Academy of Sciences
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 164, No 2 (2017)
- Pages: 191-194
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239470
- DOI: https://doi.org/10.1007/s10517-017-3955-z
- ID: 239470
Cite item
Abstract
In untreated rectal cancer patients, the chymotrypsin-like activity of proteasomes in tumor tissue was 3-fold higher than that in conventionally normal tissue, which is explained by up-regulation of expression of immunoproteasomes and total pool of proteasomes. After neoadjuvant chemoradiation therapy, expressions of the total pool of proteasomes and immunoproteasomes in the tumor as well as the relative ratios of these indices to those in conventionally normal tissue were smaller by 1.4-3.3 times in comparison with the untreated patients. These changes were paralleled with pronounced (4.5-fold) down-regulation of proteasome activity in the tumor and a 3.7-fold decrease of activity ratio for the proteasomes in tumor and in conventionally normal tissue. The number of immunoproteasome subunits and the chymotrypsin-like activity of proteasomes can be viewed as potential markers to prognosticate effectiveness of neoadjuvant chemoradiation therapy in rectal cancer patients.
About the authors
T. M. Astakhova
N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences
Email: npsharova@bk.ru
Russian Federation, Moscow
E. V. Ivanova
Tomsk National Research Medical Center, Russian Academy of Sciences
Email: npsharova@bk.ru
Russian Federation, Tomsk
G. V. Rodoman
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: npsharova@bk.ru
Russian Federation, Moscow
I. R. Sumedi
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: npsharova@bk.ru
Russian Federation, Moscow
S. G. Afanas’ev
Tomsk National Research Medical Center, Russian Academy of Sciences
Email: npsharova@bk.ru
Russian Federation, Tomsk
A. L. Goncharov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: npsharova@bk.ru
Russian Federation, Moscow
I. V. Kondakova
Tomsk National Research Medical Center, Russian Academy of Sciences
Email: npsharova@bk.ru
Russian Federation, Tomsk
N. P. Sharova
N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences
Author for correspondence.
Email: npsharova@bk.ru
Russian Federation, Moscow