Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) with Additional Protein Domain Synthesized in  E. coli :  In Vivo  Osteoinductivity in Experimental Models on Small and Large Laboratory Animals

M. S. Bartov; A. V. Gromov; V. N. Manskih; E. B. Makarova; A. P. Rubshtein; M. S. Poponova; D. M. Savina; K. S. Savin; K. E. Nikitin; T. M. Grunina; I. S. Boksha; P. A. Orlova; M. S. Krivozubov; M. E. Subbotina; V. G. Lunin; A. S. Karyagina; A. L. Gintsburg

doi:10.1007/s10517-017-3945-1

Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) with Additional Protein Domain Synthesized in E. coli: In Vivo Osteoinductivity in Experimental Models on Small and Large Laboratory Animals

作者: Bartov M.¹, Gromov A.¹, Manskih V.¹^,2, Makarova E.³, Rubshtein A.⁴, Poponova M.¹, Savina D.¹, Savin K.¹, Nikitin K.¹, Grunina T.¹, Boksha I.¹, Orlova P.¹, Krivozubov M.¹, Subbotina M.¹^,5, Lunin V.¹^,5, Karyagina A.¹^,2^,5, Gintsburg A.¹
隶属关系:
1. N. F. Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation
2. A. N. Belozersky Research Institute of Physicochemical Biology, M. V. Lomonosov Moscow State University
3. Center of Specialized Types of Medical Care, V.D. Chaklin Ural Institute of Traumatology and Orthopedics
4. M. N. Mikheev Institute of Metal Physics, Ural Division of the Russian Academy of Sciences
5. All-Russian Research Institute of Agricultural Biotechnology
期: 卷 164, 编号 2 (2017)
页面: 148-151
栏目: Biophysics and Biochemistry
URL: https://journals.rcsi.science/0007-4888/article/view/239433
DOI: https://doi.org/10.1007/s10517-017-3945-1
ID: 239433

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Recombinant human bone morphogenetic protein-2 with an additional s-tag domain (s-tag-BMP-2) synthesized in E. coli is characterized by higher solubility and activity than the protein without additional s-tag domain, which increases the yield during purification and simplifies protein introduction into the osteoplastic materials. The high osteoinductivity of the demineralized bone matrix with s-tag-BMP-2 was shown on the model of regeneration of cranial defects of a critical size in mice and on the model of implantation of porous titanium matrix into defects of femoral and tibial bones in rabbits.

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Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) with Additional Protein Domain Synthesized in E. coli: In Vivo Osteoinductivity in Experimental Models on Small and Large Laboratory Animals

全文:

详细

作者简介

M. Bartov

A. Gromov

V. Manskih

E. Makarova

A. Rubshtein

M. Poponova

D. Savina

K. Savin

K. Nikitin

T. Grunina

I. Boksha

P. Orlova

M. Krivozubov

M. Subbotina

V. Lunin

A. Karyagina

A. Gintsburg