Results of Experimental Ligation of the Main Vein with the Use of Cell Technologies
- 作者: Maiborodin I.1, Morozov V.1, Matveeva V.1, Anikeev A.1, Figurenko N.1, Maslov R.1, Chastikin G.1, Maiborodina V.2
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隶属关系:
- Center of New Medical Technologies, Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences
- Laboratory of Ultrastructural Bases of Pathology, Institute of Molecular Pathology and Pathomorphology
- 期: 卷 164, 编号 1 (2017)
- 页面: 61-67
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239361
- DOI: https://doi.org/10.1007/s10517-017-3926-4
- ID: 239361
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详细
Autologous multipotent mesenchymal stromal cells (MMSC) of bone marrow origin with transfected GFP gene and additionally stained cell membranes were injected to rats through the skin in the projection of ligated femoral vein. The results were evaluated by fluorescent microscopy. No signs of MMSC incorporation into the wall of ligated vessel or reorganized collaterals were detected. Angiogenesis processes involving MMSC were detected in experimental rats within just 4 days and progressed until week 2 postinjection, mainly in granulations at the site of surgical intervention and the cicatrix forming there. Injected MMSC completely formed all tunics of the new vessels and incorporated in the vessels forming from the recipient cells. MMSC and the objects created from them were gradually eliminated with participation of macrophages and replaced by structures formed from the recipient cells.
作者简介
I. Maiborodin
Center of New Medical Technologies, Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
V. Morozov
Center of New Medical Technologies, Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
V. Matveeva
Center of New Medical Technologies, Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
A. Anikeev
Center of New Medical Technologies, Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
N. Figurenko
Center of New Medical Technologies, Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
R. Maslov
Center of New Medical Technologies, Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
G. Chastikin
Center of New Medical Technologies, Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
V. Maiborodina
Laboratory of Ultrastructural Bases of Pathology, Institute of Molecular Pathology and Pathomorphology
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk