Study of Sedative Tea Phytocomplex within the Framework of Studies Aimed at Creation of a Rectal Dosage Form with Antihistaminic Effect
- 作者: Kulikovskii V.1, Zhilyakova E.1, Novikov O.1, Pisarev D.1, Prokushchenko N.1, Ivanova L.1
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隶属关系:
- Belgorod State National Research University
- 期: 卷 163, 编号 6 (2017)
- 页面: 753-756
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239234
- DOI: https://doi.org/10.1007/s10517-017-3896-6
- ID: 239234
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详细
We designed a new complex drug with antiallergic effect containing, in addition to the main component loratadine, a phytocomplex for an extra therapeutic effect. A collection of plants with sedative activity is chosen and the optimal agent for extraction of bioactive compounds (40% ethanol) and optimal degree of plant fragmentation are determined. Chemical composition of the sedative tea is evaluated by reverse phase HPLC. The marker components of the species are detected: xanthohumol and isoxanthohumol — Humulus lupulus cone components, Mentha piperita rosmarinic acid, and scutellareine, Menyanthes trifolia element — quercetin-3-rutinoside, and caffeic acid. Standardization of the species by the absolute graduation method in conversion to quercetin-3-rutinoside is suggested.
作者简介
V. Kulikovskii
Belgorod State National Research University
Email: pisarev@bsu.edu.ru
俄罗斯联邦, Belgorod
E. Zhilyakova
Belgorod State National Research University
Email: pisarev@bsu.edu.ru
俄罗斯联邦, Belgorod
O. Novikov
Belgorod State National Research University
Email: pisarev@bsu.edu.ru
俄罗斯联邦, Belgorod
D. Pisarev
Belgorod State National Research University
编辑信件的主要联系方式.
Email: pisarev@bsu.edu.ru
俄罗斯联邦, Belgorod
N. Prokushchenko
Belgorod State National Research University
Email: pisarev@bsu.edu.ru
俄罗斯联邦, Belgorod
L. Ivanova
Belgorod State National Research University
Email: pisarev@bsu.edu.ru
俄罗斯联邦, Belgorod