Gene—Gene Interactions of Apolipoprotein Gene Polymorphic Variants in Adolescents with Essential Arterial Hypertension and Dyslipidemia
- 作者: Kalyuzhnaya O.1, Bairova T.1, Kolesnikova L.1
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隶属关系:
- Research Center of Family Health and Human Reproduction Problems
- 期: 卷 163, 编号 4 (2017)
- 页面: 456-460
- 栏目: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/238989
- DOI: https://doi.org/10.1007/s10517-017-3827-6
- ID: 238989
如何引用文章
详细
Using MDR bioinformatic analysis we studied gene—gene interactions between apolipoprotein genes in adolescents with essential arterial hypertension and dyslipidemia against the background of essential arterial hypertension. Optimal models of gene—gene interactions were formed. The six-locus model was the most significant: (ApoA1(+83T), ApoA1(-75A), ApoB(Del), ApoC3(S2), ApoE(ε2), ApoE(ε4). The maximum synergism in both adolescent groups were shown for allele variants ApoA1(-75A), ApoB(Del), and ApoE(ε4). The maximum contribution to gene—gene interactions entropy was made by allelic polymorphisms ApoA1(-75A) and ApoE(ε4) and (in the comorbid pathology group) for ApoE(ε4)+ApoB(Del).
作者简介
O. Kalyuzhnaya
Research Center of Family Health and Human Reproduction Problems
编辑信件的主要联系方式.
Email: kaluzhnayao@yandex.ru
俄罗斯联邦, Irkutsk
T. Bairova
Research Center of Family Health and Human Reproduction Problems
Email: kaluzhnayao@yandex.ru
俄罗斯联邦, Irkutsk
L. Kolesnikova
Research Center of Family Health and Human Reproduction Problems
Email: kaluzhnayao@yandex.ru
俄罗斯联邦, Irkutsk