Gene—Gene Interactions of Apolipoprotein Gene Polymorphic Variants in Adolescents with Essential Arterial Hypertension and Dyslipidemia
- Авторы: Kalyuzhnaya O.1, Bairova T.1, Kolesnikova L.1
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Учреждения:
- Research Center of Family Health and Human Reproduction Problems
- Выпуск: Том 163, № 4 (2017)
- Страницы: 456-460
- Раздел: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/238989
- DOI: https://doi.org/10.1007/s10517-017-3827-6
- ID: 238989
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Аннотация
Using MDR bioinformatic analysis we studied gene—gene interactions between apolipoprotein genes in adolescents with essential arterial hypertension and dyslipidemia against the background of essential arterial hypertension. Optimal models of gene—gene interactions were formed. The six-locus model was the most significant: (ApoA1(+83T), ApoA1(-75A), ApoB(Del), ApoC3(S2), ApoE(ε2), ApoE(ε4). The maximum synergism in both adolescent groups were shown for allele variants ApoA1(-75A), ApoB(Del), and ApoE(ε4). The maximum contribution to gene—gene interactions entropy was made by allelic polymorphisms ApoA1(-75A) and ApoE(ε4) and (in the comorbid pathology group) for ApoE(ε4)+ApoB(Del).
Об авторах
O. Kalyuzhnaya
Research Center of Family Health and Human Reproduction Problems
Автор, ответственный за переписку.
Email: kaluzhnayao@yandex.ru
Россия, Irkutsk
T. Bairova
Research Center of Family Health and Human Reproduction Problems
Email: kaluzhnayao@yandex.ru
Россия, Irkutsk
L. Kolesnikova
Research Center of Family Health and Human Reproduction Problems
Email: kaluzhnayao@yandex.ru
Россия, Irkutsk