Gene—Gene Interactions of Apolipoprotein Gene Polymorphic Variants in Adolescents with Essential Arterial Hypertension and Dyslipidemia
- Authors: Kalyuzhnaya O.V.1, Bairova T.A.1, Kolesnikova L.I.1
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Affiliations:
- Research Center of Family Health and Human Reproduction Problems
- Issue: Vol 163, No 4 (2017)
- Pages: 456-460
- Section: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/238989
- DOI: https://doi.org/10.1007/s10517-017-3827-6
- ID: 238989
Cite item
Abstract
Using MDR bioinformatic analysis we studied gene—gene interactions between apolipoprotein genes in adolescents with essential arterial hypertension and dyslipidemia against the background of essential arterial hypertension. Optimal models of gene—gene interactions were formed. The six-locus model was the most significant: (ApoA1(+83T), ApoA1(-75A), ApoB(Del), ApoC3(S2), ApoE(ε2), ApoE(ε4). The maximum synergism in both adolescent groups were shown for allele variants ApoA1(-75A), ApoB(Del), and ApoE(ε4). The maximum contribution to gene—gene interactions entropy was made by allelic polymorphisms ApoA1(-75A) and ApoE(ε4) and (in the comorbid pathology group) for ApoE(ε4)+ApoB(Del).
About the authors
O. V. Kalyuzhnaya
Research Center of Family Health and Human Reproduction Problems
Author for correspondence.
Email: kaluzhnayao@yandex.ru
Russian Federation, Irkutsk
T. A. Bairova
Research Center of Family Health and Human Reproduction Problems
Email: kaluzhnayao@yandex.ru
Russian Federation, Irkutsk
L. I. Kolesnikova
Research Center of Family Health and Human Reproduction Problems
Email: kaluzhnayao@yandex.ru
Russian Federation, Irkutsk