Study of Endothelial Protective Activity of Phenol-Derived Thrombin and Arginase-2 Inhibitors KUD-259 and KUD-974

M. V. Pokrovskii; M. V. Korokin; K. V. Kudryavtsev; T. G. Pokrovskaya; O. S. Gudyrev; V. V. Gureev; L. V. Korokina; S. V. Povetkin

doi:10.1007/s10517-017-3822-y

Study of Endothelial Protective Activity of Phenol-Derived Thrombin and Arginase-2 Inhibitors KUD-259 and KUD-974

作者: Pokrovskii M.¹, Korokin M.¹, Kudryavtsev K.¹, Pokrovskaya T.¹, Gudyrev O.¹, Gureev V.¹, Korokina L.¹, Povetkin S.¹
隶属关系:
1. Department of Pharmacology, Medical School, Belgorod State University
期: 卷 163, 编号 4 (2017)
页面: 436-438
栏目: Article
URL: https://journals.rcsi.science/0007-4888/article/view/238968
DOI: https://doi.org/10.1007/s10517-017-3822-y
ID: 238968

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We performed correction of endothelial dysfunction with phenol derivatives KUD-259 and KUD-974 containing heteroatomic and heterocyclic structures. Pharmacological activity of KUD-259 and KUD-974 surpassed that of L-norvaline, a non-selective arginase inhibitor.